Given the success of british art venues such as the Tate, i wouldn't hesitate to reccomend the SF MOMA to anyone and everyone.
The building has fantastic architecture showcasing a broad spectra of modern art from the US and abroad. The entry price is reasonable and the queues aren't all too bad - they move 'em quickly.
Typically they have the permanent exhibitions and support those with special exhibitions. These in themselves can consist of virtually every conceivable media and most likely will.
Like all good musuems, you can pick up an audio guide, which i think also caters to multiple languages. When i was there it wasn't hugely packed - if you've been to the Tate Modern, then this isn't nearly as bad.
Check it out though make sure you get there early, or you'll miss bits.
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